Introduction：Basic information about CAS 551-74-6|D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI) |
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| CAS Number | 551-74-6 | Molecular Weight | 378.12100 |
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| Density | / | Boiling Point | 541.9ºC at 760 mmHg |
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| Molecular Formula | C10H24Cl4N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 281.5ºC |
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Names
| Name | (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol,dihydrochloride |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Boiling Point | 541.9ºC at 760 mmHg |
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| Molecular Formula | C10H24Cl4N2O4 |
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| Molecular Weight | 378.12100 |
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| Flash Point | 281.5ºC |
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| Exact Mass | 376.04900 |
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| PSA | 104.98000 |
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| LogP | 0.47260 |
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| Vapour Pressure | 5.27E-14mmHg at 25°C |
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| InChIKey | GBKLAYXZNQSPBS-XYSQQLOGSA-N |
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| SMILES | Cl.Cl.OC(CNCCCl)C(O)C(O)C(O)CNCCCl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OP2275000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, dihydrochloride, D-
- CAS REGISTRY NUMBER :
- 551-74-6
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4.2Cl-H
- MOLECULAR WEIGHT :
- 378.16
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G &GH 2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 7600 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - thrombocytopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia Blood - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 260 mg/kg/4D-I
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in spleen Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23 mg/kg/4W
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7265 ug/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- DNA damage
MUTATION DATA - TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Escherichia coli
- DOSE/DURATION :
- 1 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,190,1973 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,157,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,157,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
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Synonyms
| 1,6-Bis(chloroethylamino)-1,6-desoxymannitol dihydrochloride |
| Mannitol,1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,dihydrochloride,D |
| Degranol |
| Degranol chinoin |
| Mannomustine dihydrochloride |
| D-Mannitol,1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,dihydrochloride |
| 1,6-Dideoxy-1,6-di(2-chloroethylamino)-D-mannitol dihydrochloride |
