Introduction：Basic information about CAS 552-59-0|Prunetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Prunetin |
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| CAS Number | 552-59-0 | Molecular Weight | 284.263 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 546.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O5 | Melting Point | 240-242ºC |
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| MSDS | ChineseUSA | Flash Point | 209.7±23.6 °C |
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Names
| Name | prunetin |
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| Synonym | More Synonyms |
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Prunetin BiologicalActivity
| Description | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Aldehyde Dehydrogenase (ALDH)Research Areas >>Inflammation/Immunology |
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| In Vitro | Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[1]. |
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| References | [1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477. [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 546.5±50.0 °C at 760 mmHg |
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| Melting Point | 240-242ºC |
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| Molecular Formula | C16H12O5 |
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| Molecular Weight | 284.263 |
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| Flash Point | 209.7±23.6 °C |
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| Exact Mass | 284.068481 |
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| PSA | 79.90000 |
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| LogP | 3.53 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.669 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DJ3100050
- CHEMICAL NAME :
- 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-
- CAS REGISTRY NUMBER :
- 552-59-0
- BEILSTEIN REFERENCE NO. :
- 0292155
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H12-O5
- MOLECULAR WEIGHT :
- 284.28
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | DJ3100050 |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one |
| Prunusetin |
| 5,4'-dihydroxy-7-methoxyisoflavone |
| Prunetin |
| 7-methoxy-4',5-dihydroxyisoflavone |
| 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one |
| 7-O-methyl-genistein |
| 4',5-dihydroxy-7-methoxyisoflavone |
| 4',5-dihydroxy-7-methoxygenistein |
| 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy- |
| EINECS 209-018-5 |
| MFCD00016951 |
