Introduction：Basic information about CAS 84-96-8|Trimeprazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimeprazine |
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| CAS Number | 84-96-8 | Molecular Weight | 298.44600 |
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| Density | 1.203 g/cm3 | Boiling Point | 420.3ºC at 760mmHg |
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| Molecular Formula | C18H22N2S | Melting Point | 68°C |
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| MSDS | / | Flash Point | 208ºC |
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Names
| Name | N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine |
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| Synonym | More Synonyms |
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Trimeprazine BiologicalActivity
| Description | Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| Target | HA receptor[1] |
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| References | [1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. [2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3). |
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Chemical & Physical Properties
| Density | 1.203 g/cm3 |
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| Boiling Point | 420.3ºC at 760mmHg |
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| Melting Point | 68°C |
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| Molecular Formula | C18H22N2S |
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| Molecular Weight | 298.44600 |
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| Flash Point | 208ºC |
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| Exact Mass | 298.15000 |
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| PSA | 31.78000 |
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| LogP | 4.55200 |
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| InChIKey | ZZHLYYDVIOPZBE-UHFFFAOYSA-N |
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| SMILES | CC(CN(C)C)CN1c2ccccc2Sc2ccccc21 |
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| Water Solubility | 0.942 mg/L |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SO5700000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-
- CAS REGISTRY NUMBER :
- 84-96-8
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-S
- MOLECULAR WEIGHT :
- 298.48
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B1Y1&1N1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4969 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 333 (estimated) No. of Female Employees: 227 (estimated)
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . |
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| RIDADR | 2811 |
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| WGK Germany | 3 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| Methylpromazine |
| Isobutrazine |
| EINECS 201-577-3 |
| Repetin |
| Alimemazine |
| N,N-dimethyl-N-<2-methyl-3-(10H-10-phenothiazinyl)propyl>amine |
| Alimezine |
| dl-Trimeprazine |
| Teralen |
| 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine |
| Trimeprazine |
