CAS 530-43-8|Chloramphenicol palmitate
Introduction：Basic information about CAS 530-43-8|Chloramphenicol palmitate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chloramphenicol palmitate | ||
|---|---|---|---|
| CAS Number | 530-43-8 | Molecular Weight | 561.538 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 691.6±55.0 °C at 760 mmHg |
| Molecular Formula | C27H42Cl2N2O6 | Melting Point | 90ºC |
| MSDS | ChineseUSA | Flash Point | 372.1±31.5 °C |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | chloramphenicol palmitate |
|---|---|
| Synonym | More Synonyms |
Chloramphenicol palmitate BiologicalActivity
| Description | Chloramphenicol palmitate is an orally active broad spectrum antibiotic and has a broad spectrum of activity against gram positive and gram negative bacteria. Chloramphenicol palmitate inhibits bacterial protein synthesis by blocking the peptidyl transferase step. Chloramphenicol palmitate can be used as bacterial selection agent in transformed cells containing chloramphenicol resistance genes[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. Siti Nani Nurbaeti, et al. Sustained-release Microparticle Dry Powders of Chloramphenicol Palmitate or Thiamphenicol Palmitate Prodrugs for Lung Delivery as Aerosols.Eur J Pharm Sci. 2019 Oct 1;138:105028. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 691.6±55.0 °C at 760 mmHg |
| Melting Point | 90ºC |
| Molecular Formula | C27H42Cl2N2O6 |
| Molecular Weight | 561.538 |
| Flash Point | 372.1±31.5 °C |
| Exact Mass | 560.242004 |
| PSA | 121.45000 |
| LogP | 9.04 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.526 |
| InChIKey | PXKHGMGELZGJQE-ILBGXUMGSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)OCC(NC(=O)C(Cl)Cl)C(O)c1ccc([N+](=O)[O-])cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2640 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,248,1982 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1200 mg/kg
- SEX/DURATION :
- female 7-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.1- 1887- Volume(issue)/page/year: 71,623,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2340 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 318 (estimated) No. of Female Employees: 132 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R40 |
| Safety Phrases | 36/37-36-26 |
| RIDADR | NONH for all modes of transport |
| RTECS | RT4735000 |
| HS Code | 29414000 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles22
More Articles| Structural, electronic, thermodynamical and charge transfer properties of Chloramphenicol Palmitate using vibrational spectroscopy and DFT calculations. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 101 , 335-42, (2013) The global problem of advancing bacterial resistance to newer drugs has led to renewed interest in the use of Chloramphenicol Palmitate (C27H42Cl2N2O6) [Palmitic acid alpha ester with D-threo-(-),2-di... | |
| Metabolism of some drugs by intestinal lactobacilli and their toxicological considerations. Acta Pharmacol. Toxicol. (Copenh.) 58(1) , 11-5, (1986) The bacterial metabolism of three drugs (sulphasalazine, phthalylsulphathiazole and chloramphenicol palmitate) and two dyes (tartrazine and methyl red) has been studied using a resting culture techniq... | |
| The effect of exocrine pancreatic function on chloramphenicol pharmacokinetics in patients with cystic fibrosis. Pediatr. Res. 23(4) , 388-92, (1988) The effect of exocrine pancreatic function on the pharmacokinetics of the choramphenicol oral capsule (CAP-base), chloramphenicol palmitate oral liquid (CAP-P), and chloramphenicol succinate intraveno... |
Synonyms
| Chlorambon |
| detreopal |
| CHLORAMPHENICOLPALMITATE,BP |
| cap-palmitate |
| Chloramphenicol palmitate |
| Clorolifarina |
| chloromycetinpalmitate |
| Hexadecanoic acid, (2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester |
| CHLORAMPHENICAL PALMITATE |
| (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl hexadecanoate |
| D-threo-(-)-2,2-Dichloro-N-(β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl)acetamide α-palmitate |
| EINECS 208-477-9 |
| MFCD00083597 |
| CAP-P |
| Chloramphenicol palmitate (ester) |
| chloramphenicol 3'-palmitate |
| (2R,3R)-2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl palmitate |
| [R-(R*,R*)]-Hexadecanoic Acid 2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl Ester |
| Chloropal |
| D-threo-(-)-2,2-Dichloro-N-(b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl)acetamide a-Palmitate |
| chlorophenicol palmitate |
