CAS 68181-17-9|SPDP
| Common Name | SPDP | ||
|---|---|---|---|
| CAS Number | 68181-17-9 | Molecular Weight | 312.365 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 465.9±55.0 °C at 760 mmHg |
| Molecular Formula | C12H12N2O4S2 | Melting Point | 84-86 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 235.6±31.5 °C |
Names
| Name | N-Succinimidyl 3-(2-Pyridyldithio)propionate |
|---|---|
| Synonym | More Synonyms |
SPDP BiologicalActivity
| Description | SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| References | [1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 465.9±55.0 °C at 760 mmHg |
| Melting Point | 84-86 °C(lit.) |
| Molecular Formula | C12H12N2O4S2 |
| Molecular Weight | 312.365 |
| Flash Point | 235.6±31.5 °C |
| Exact Mass | 312.023834 |
| PSA | 127.17000 |
| LogP | 0.99 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.650 |
| InChIKey | JWDFQMWEFLOOED-UHFFFAOYSA-N |
| SMILES | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O |
| Storage condition | −20°C |
| Water Solubility | acetone: 50 mg/mL |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Synonyms
| MFCD00009636 |
| 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione |
| EINECS 269-034-3 |
| N-succinimidyl 3-(2-pyridyldithio)-propionate |
| (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate |
| 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione |
| 2,5-Pyrrolidinedione, 1-[1-oxo-3-(2-pyridinyldithio)propoxy]- |
| 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione |
| 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- |
| SPDP |
