Introduction：Basic information about CAS 73-49-4|Quinethazone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Quinethazone |
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| CAS Number | 73-49-4 | Molecular Weight | 289.739 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C10H12ClN3O3S | Melting Point | 250 - 252ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide |
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| Synonym | More Synonyms |
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Quinethazone BiologicalActivity
| Description | Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Carbonic Anhydrase |
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| In Vivo | Quinethazone (50 mg/kg; p.o.; daily for 2 weeks) lowers blood pressure of renal hypertensive rats in association with a decrease in potassium but no change in water or sodium contents of aorta wall[1]. Animal Model: Five- to 6-week-old Long Evans male rats, hypertension model[1] Dosage: 50 mg/kg Administration: Oral, daily for 2 weeks Result: Had no significant effect on sodium or water distribution in arterial tissue of hypertensive rats, but decreased approximate 20% intra-cellular content of potassium |
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| References | [1]. FREED SC. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proc Soc Exp Biol Med. 1963 Nov;114:421-2. [2]. Angelopoulos B, et al. Experimental investigation and observations on the diuretic action of quinethazone. Med Pharmacol Exp Int J Exp Med. 1966;14(6):528-36. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Melting Point | 250 - 252ºC |
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| Molecular Formula | C10H12ClN3O3S |
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| Molecular Weight | 289.739 |
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| Exact Mass | 289.028778 |
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| PSA | 109.67000 |
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| LogP | 0.49 |
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| Index of Refraction | 1.582 |
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| InChIKey | AGMMTXLNIQSRCG-UHFFFAOYSA-N |
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| SMILES | CCC1NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2N1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VA1679500
- CHEMICAL NAME :
- 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-ethyl-4-oxo-
- CAS REGISTRY NUMBER :
- 73-49-4
- BEILSTEIN REFERENCE NO. :
- 0818554
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H12-Cl-N3-O3-S
- MOLECULAR WEIGHT :
- 289.76
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,201,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5486 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Quimethazin |
| Quinethazonum |
| Hydromox |
| Quinetazona |
| Quinethazon |
| Chinethazonum |
| 7-Chlor-6-sulfamoyl-2-aethyl-4-oxo-1,2,3,4-tetrahydro-chinazolin |
| UNII:455E0S048W |
| 6-Quinazolinesulfonamide, 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo- |
| 7-Chlor-2-aethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-chinazolinon |
| quinethazone |
| 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydro-quinazoline-6-sulfonic acid amide |
| 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide |
| Aquamox |
| 7-Chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydro-6-quinazolinesulfonamide |
| 7-Chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
| Idrokin |
