Introduction：Basic information about CAS 73815-11-9|CIMOXATONE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CIMOXATONE |
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| CAS Number | 73815-11-9 | Molecular Weight | 338.35700 |
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| Density | 1.29g/cm3 | Boiling Point | 509.3ºC at 760 mmHg |
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| Molecular Formula | C19H18N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 261.8ºC |
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Names
| Name | 3-[[4-[5-(methoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]methyl]benzonitrile |
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| Synonym | More Synonyms |
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CIMOXATONE BiologicalActivity
| Description | Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A)[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Metabolic Disease |
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| Target | MAO-A |
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| In Vivo | Cimoxatone (20 mg/kg; p.o.) 增强 5-HT (1 mg/kg; s.c.) 对大鼠的厌食作用[1]。 Animal Model: 250-300 g, Adult male Wistar rats[1] Dosage: 20 mg/kg Administration: P.o. Result: Significiantly reduced sucrose intake induced by 1 mg/kg 5-HT or its vehicle injected 2 and 24 h later, significantly enhanced the anorectic action of 5-HT at 2 h but not at 24 h. |
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Chemical & Physical Properties
| Density | 1.29g/cm3 |
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| Boiling Point | 509.3ºC at 760 mmHg |
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| Molecular Formula | C19H18N2O4 |
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| Molecular Weight | 338.35700 |
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| Flash Point | 261.8ºC |
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| Exact Mass | 338.12700 |
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| PSA | 71.79000 |
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| LogP | 3.17388 |
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| Index of Refraction | 1.613 |
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| InChIKey | MVVJINIUPYKZHR-UHFFFAOYSA-N |
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| SMILES | COCC1CN(c2ccc(OCc3cccc(C#N)c3)cc2)C(=O)O1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DI4710000
- CHEMICAL NAME :
- Benzonitrile, 3-((4-(5-(methoxymethyl)-2-oxo-3-oxazolidinyl)phenoxy )methyl)-
- CAS REGISTRY NUMBER :
- 73815-11-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H18-N2-O4
- MOLECULAR WEIGHT :
- 338.39
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982
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Synonyms
| Cimoxatone |
| Cimoxatone (INN) |
| Cimoxatonum [INN-Latin] |
| EINECS 277-613-7 |
| Cimoxatono [INN-Spanish] |
