Introduction：Basic information about CAS 75821-71-5|LONAZOLAC CALCIUM SALT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LONAZOLAC CALCIUM SALT |
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| CAS Number | 75821-71-5 | Molecular Weight | 663.56300 |
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| Density | / | Boiling Point | 525.1ºC at 760 mmHg |
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| Molecular Formula | C34H24CaCl2N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | 271.4ºC |
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Names
| Name | lonazolac calcium |
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| Synonym | More Synonyms |
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LONAZOLAC CALCIUM SALT BiologicalActivity
| Description | Lonazolac (hemicalcium) is the calcium salt form of Lonazolac. Lonazolac is a nonsteroidal antirheumatic agent with anti-inflammatory properties[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| References | [1]. Trnavský K, et al. [Lonazolac - a new non-steroidal antirheumatic agent. Report of a double-blind crossover clinical study]. Fysiatr Revmatol Vestn. 1983;61(3):147-152. |
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Chemical & Physical Properties
| Boiling Point | 525.1ºC at 760 mmHg |
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| Molecular Formula | C34H24CaCl2N4O4 |
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| Molecular Weight | 663.56300 |
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| Flash Point | 271.4ºC |
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| Exact Mass | 662.08000 |
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| PSA | 115.90000 |
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| LogP | 4.97020 |
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| InChIKey | CAQGVXNKMLYRMF-UHFFFAOYSA-L |
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| SMILES | O=C([O-])Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1.O=C([O-])Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1.[Ca+2] |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UQ4915000
- CAS REGISTRY NUMBER :
- 75821-71-5
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C34-H24-Cl2-N4-O4.Ca
- MOLECULAR WEIGHT :
- 663.60
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 845 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 670 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982
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Synonyms
| LONAZOLAC CALCIUM SALT |
| Arthro akut |
| Bis[1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-acetic acid]calcium salt |
| Argun l |
| Irritren |
| calcium bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetate] |
| Lonazolac calcium |
| 1H-Pyrazole-4-acetic acid,3-(4-chlorophenyl)-1-phenyl-,calcium salt (2:1) |
| Bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid]calcium salt |
