CAS 7081-40-5|Metixene hydrochloride hydrate
Introduction：Basic information about CAS 7081-40-5|Metixene hydrochloride hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Metixene hydrochloride hydrate | ||
|---|---|---|---|
| CAS Number | 7081-40-5 | Molecular Weight | 363.94500 |
| Density | / | Boiling Point | 419.7ºC at 760 mmHg |
| Molecular Formula | C20H26ClNOS | Melting Point | 215-217° |
| MSDS | / | Flash Point | / |
Names
| Name | methixene hydrochloride |
|---|---|
| Synonym | More Synonyms |
Metixene hydrochloride hydrate BiologicalActivity
| Description | Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease |
| Target | IC50: 55 nM (mAChR)[1] Ki: 15 nM (mAChR)[1] |
| In Vitro | Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1]. |
| References | [1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4. |
Chemical & Physical Properties
| Boiling Point | 419.7ºC at 760 mmHg |
|---|---|
| Melting Point | 215-217° |
| Molecular Formula | C20H26ClNOS |
| Molecular Weight | 363.94500 |
| Exact Mass | 363.14200 |
| PSA | 37.77000 |
| LogP | 5.69060 |
| InChIKey | RAOHHYUBMJLHNC-UHFFFAOYSA-N |
| SMILES | CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1.Cl.O |
Safety Information
| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles8
More Articles| [An anticholinergic agent, the side effect of mouth dryness and hazards for the teeth]. Ned. Tijdschr. Geneeskd. 127(51) , 2318-21, (1983) | |
| Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism. J. Neural Transm. Suppl. 25 , 137-47, (1987) To quantify the clinical benefit of an additional deprenyl administration in L-dopa pretreated patients we have performed a study of 30 patients suffering from advanced parkinsonism. During the first ... | |
| Evaluation of an antispasmodic agent. Methixene hydrochloride (Trest). JAMA 195(10) , 851, (1966) Methixene hydrochloride, an anticholinergic agent, may be useful in the symptomatic treatment of functional bowel disorders. Adverse effects reported from its use are those of the anticholinergic drug... |
Synonyms
| 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride hydrete |
| Methixene hydrochloride hydrete |
| Methixene hydrochloride hydrate |
