Introduction：Basic information about CAS 215874-86-5|Α5ia (α5IA), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Α5ia (α5IA) |
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| CAS Number | 215874-86-5 | Molecular Weight | 362.34500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C17H14N8O2 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | 5-methyl-3-[6-[(1-methyltriazol-4-yl)methoxy]-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-1,2-oxazole |
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| Synonym | More Synonyms |
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Α5ia (α5IA) BiologicalActivity
| Description | α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| In Vitro | α5IA (100 nM, 5 days) 可以使小鼠原代海马培养物中 Aβ 1-42 诱导的细胞死亡显着减少[1]。 Cell Viability Assay[1] Cell Line: Primary mouse hippocampal culture Concentration: 0.3 nM, 3 nM, 30 nM, 100 nM Incubation Time: 24 h Result: Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM. Significantly decreased the expression of GABAAR α5 subunit. |
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| In Vivo | α5IA (5 mg/kg, i.p., once) 可持续恢复 Ts65Dn 小鼠的空间学习能力，以及长期识别的空间记忆缺陷[2]。 |
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| References | [1]. Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21(9):3284. [2]. Arnaud Duchon, et al. Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177(5):1106-1118. |
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Chemical & Physical Properties
| Molecular Formula | C17H14N8O2 |
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| Molecular Weight | 362.34500 |
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| Exact Mass | 362.12400 |
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| PSA | 109.05000 |
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| LogP | 1.94840 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3-(5-methylisoazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3,4-a]phthalazine |
| | inverted exclamation mark5IA |
| |A5IA |
| 3-(5-methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3,4-a]phthalazine |
