CAS 80434-82-8|20-hydroxy-20-oxoleukotriene B4
Introduction：Basic information about CAS 80434-82-8|20-hydroxy-20-oxoleukotriene B4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 20-hydroxy-20-oxoleukotriene B4 | ||
|---|---|---|---|
| CAS Number | 80434-82-8 | Molecular Weight | 366.449 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 588.3±50.0 °C at 760 mmHg |
| Molecular Formula | C20H30O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 323.6±26.6 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | 20-hydroxy-20-oxo-leukotriene B4 |
|---|---|
| Synonym | More Synonyms |
20-hydroxy-20-oxoleukotriene B4 BiologicalActivity
| Description | 20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis)[1]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Anne-Sophie Archambault, et al. 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils. J Leukoc Biol. 2019 Jun;105(6):1131-1142. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.3±50.0 °C at 760 mmHg |
| Molecular Formula | C20H30O6 |
| Molecular Weight | 366.449 |
| Flash Point | 323.6±26.6 °C |
| Exact Mass | 366.204254 |
| PSA | 115.06000 |
| LogP | 2.02 |
| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
| Index of Refraction | 1.548 |
| InChIKey | SXWGPVJGNOLNHT-VFLUTPEKSA-N |
| SMILES | O=C(O)CCCCC=CCC(O)C=CC=CC=CC(O)CCCC(=O)O |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H315-H319-H335 |
| Precautionary Statements | P210-P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F,Xi |
| Risk Phrases | 11-36/37/38 |
| Safety Phrases | 16-26-36 |
| RIDADR | UN 1170 3/PG 2 |
Articles14
More Articles| The human serum metabolome. PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m... | |
| Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Lett. 130(1) , 107-12, (1981) | |
| Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome. J. Neurol. Sci. 183(1) , 61-7, (2001) The Sjögren-Larsson Syndrome (SLS) is a neurocutaneous disorder, caused by deficient activity of the microsomal enzyme fatty aldehyde dehydrogenase (FALDH). FALDH catalyzes the oxidation of medium- an... |
Synonyms
| (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenedioic acid |
| 20-carboxy-LTB4 |
| 20-hydroxy-20-oxoleukotriene B4 |
| 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraene-1,20-dioic acid |
| 6,8,10,14-Eicosatetraenedioic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)- |
| 5,12-Dihydroxy-delta5,8,11,14-eicosapolyendioic acid |
| 20-COOH-LTB4 |
| (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid |
| 20-carboxyleukotriene B4 |
| 20-COOH-Leukotriene B4 |
| MFCD00065857 |
