Introduction：Basic information about CAS 537-05-3|Guanicaine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Guanicaine |
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| CAS Number | 537-05-3 | Molecular Weight | 427.92400 |
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| Density | / | Boiling Point | 545.9ºC at 760mmHg |
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| Molecular Formula | C23H26ClN3O3 | Melting Point | / |
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| MSDS | / | Flash Point | 284ºC |
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Names
| Name | 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine,hydrochloride |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Boiling Point | 545.9ºC at 760mmHg |
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| Molecular Formula | C23H26ClN3O3 |
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| Molecular Weight | 427.92400 |
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| Flash Point | 284ºC |
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| Exact Mass | 427.16600 |
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| PSA | 64.11000 |
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| LogP | 6.26220 |
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| InChIKey | ZQWBGSZBBGYKNV-UHFFFAOYSA-N |
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| SMILES | CCOc1ccc(N=C(Nc2ccc(OC)cc2)Nc2ccc(OC)cc2)cc1.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MF2000000
- CHEMICAL NAME :
- Guanidine, 2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 537-05-3
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C23-H25-N3-O3.Cl-H
- MOLECULAR WEIGHT :
- 427.97
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
- REFERENCE :
- HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
- REFERENCE :
- WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1043,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935
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Safety Information
Customs
| HS Code | 2925290090 |
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| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| Guanicaine |
| Acoin |
| Diparaanisyl-monophenethyl-guanidin-hydrochlorid [German] |
| 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride |
| Dianisyl-monophenethylguanidine hydrochloride |
| Akoin hydrochlorid [German] |
| Phenodianisyl |
| Phenodianisyl hydrochloride |
| Acoine |
| Acoin hydrochloride |
