Introduction：Basic information about CAS 119356-77-3|Dapoxetine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dapoxetine |
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| CAS Number | 119356-77-3 | Molecular Weight | 305.413 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 454.4±38.0 °C at 760 mmHg |
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| Molecular Formula | C21H23NO | Melting Point | / |
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| MSDS | / | Flash Point | 132.6±29.1 °C |
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Names
| Name | Dapoxetine |
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| Synonym | More Synonyms |
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Dapoxetine BiologicalActivity
| Description | Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin Transporter |
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| In Vitro | Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine. Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1] |
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| In Vivo | Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2]. Animal Model: Adult male Wistar rats[2] Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Oral gavage; 1-10 mg/kg; once daily Result: Reverted most of the changes made by testosterone injection. |
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| References | [1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89. [2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 454.4±38.0 °C at 760 mmHg |
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| Molecular Formula | C21H23NO |
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| Molecular Weight | 305.413 |
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| Flash Point | 132.6±29.1 °C |
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| Exact Mass | 305.177979 |
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| PSA | 12.47000 |
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| LogP | 5.13 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | USRHYDPUVLEVMC-FQEVSTJZSA-N |
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| SMILES | CN(C)C(CCOc1cccc2ccccc12)c1ccccc1 |
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| Storage condition | 2-8°C |
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Safety Information
Customs
| HS Code | 2922299090 |
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| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine |
| Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, (αS)- |
| Priligy |
| Dapoxetina |
| (1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine |
| Dapoxetine |
| (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine |
| (+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine |
| (S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine |
| (1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine |
| MFCD00865355 |
| (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine |
| Dapoxetinum |
