CAS 192939-46-1|ximelagatran

Introduction：Basic information about CAS 192939-46-1|ximelagatran, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ximelagatran BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	ximelagatran
CAS Number	192939-46-1	Molecular Weight	473.565
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₄H₃₅N₅O₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	ximelagatran
Synonym	More Synonyms

ximelagatran BiologicalActivity

Description	Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcokinetics and pharmacodynamics[1][2].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Thrombin
In Vitro	Ximelagatran is an orally administered direct thrombin inhibitor under development as an anticoagulant agent for prophylaxis against and treatment of thromboembolism. Ximelagatran is rapidly absorbed and quickly converted into its active form Melagatran, a reversible, active-site inhibitor of both free and clot-bound thrombin that has stable and reproducible pharmacokinetic properties. Initial studies have shown Ximelagatran to have good efficacy and safety in the prevention of venous thromboembolism after total knee or total hip replacement[3].
References	[1]. Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct;1(10):2119-30. [2]. Gao JH, et al. Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis. Medicine (Baltimore). 2017 Oct;96(40):e8059. [3]. Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₄H₃₅N₅O₅
Molecular Weight	473.565
Exact Mass	473.263824
PSA	143.85000
LogP	2.08
Index of Refraction	1.635
InChIKey	ZXIBCJHYVWYIKI-PZJWPPBQSA-N
SMILES	CCOC(=O)CNC(C(=O)N1CCC1C(=O)NCc1ccc(C(N)=NO)cc1)C1CCCCC1

Synonyms

ximelagatran

ximelagatra

Ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N-hydroxycarbamimidoyl)benzyl]carbamoyl}-1-azetidinyl]-2-oxoethyl}glycinate

Exanta

H-376/95

H 376-95

[14C]-Ximelagatran

Ethyl (((1R)-1-cyclohexyl-2-((2S)-2-((4-(hydroxycarbamimidoyl)benzyl)carbamoyl)azetidin-1-yl-2-oxoethyl)amino)acetate

H 376/95

[3H]-Ximelagatran

Ximelagatran (JAN/USAN/INN)

Exanta (TN)

Exarta

Ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate

Glycine, N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]-, ethyl ester

Ximelagatran [USAN:INN]

ethyl 2-[[(1R)-1-cyclohexyl-2-[(2S)-2-[[4-[(Z)-N'-hydroxycarbamimidoyl]phenyl]methylcarbamoyl]azetidin-1-yl]-2-oxoethyl]amino]acetate

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