CAS 86426-17-7|Mildronate
Introduction：Basic information about CAS 86426-17-7|Mildronate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mildronate | ||
|---|---|---|---|
| CAS Number | 86426-17-7 | Molecular Weight | 182.218 |
| Density | / | Boiling Point | / |
| Molecular Formula | C6H18N2O4 | Melting Point | / |
| MSDS | Chinese | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Mildronate dihydrate |
|---|---|
| Synonym | More Synonyms |
Mildronate BiologicalActivity
| Description | Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| Target | IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2). |
| References | [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. |
Chemical & Physical Properties
| Molecular Formula | C6H18N2O4 |
|---|---|
| Molecular Weight | 182.218 |
| Exact Mass | 182.126663 |
| PSA | 70.62000 |
| Appearance of Characters | white to off-white |
| InChIKey | JFWLFLLRLZSBRA-UHFFFAOYSA-N |
| SMILES | C[N+](C)(C)NCCC(=O)[O-].O.O |
| Storage condition | 2-8°C |
| Water Solubility | H2O: >40mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
Articles1
More Articles| A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application. J. AOAC Int. 97(6) , 1526-37, (2015) A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs we... |
Synonyms
| 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate |
| Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt, hydrate (1:2) |
| Mildronatedehydrate |
| 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate dihydrate |
| Mildronate |
