Introduction：Basic information about CAS 83409-32-9|Desethylamiodarone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desethylamiodarone |
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| CAS Number | 83409-32-9 | Molecular Weight | 617.25800 |
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| Density | 1.638 g/cm3 | Boiling Point | 630.3ºC at 760 mmHg |
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| Molecular Formula | C23H25I2NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 335ºC |
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Names
| Name | (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone |
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| Synonym | More Synonyms |
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Desethylamiodarone BiologicalActivity
| Description | Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| References | [1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470. [2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9. |
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Chemical & Physical Properties
| Density | 1.638 g/cm3 |
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| Boiling Point | 630.3ºC at 760 mmHg |
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| Molecular Formula | C23H25I2NO3 |
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| Molecular Weight | 617.25800 |
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| Flash Point | 335ºC |
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| Exact Mass | 616.99200 |
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| PSA | 51.47000 |
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| LogP | 6.59480 |
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| Index of Refraction | 1.635 |
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| InChIKey | VXOKDLACQICQFA-UHFFFAOYSA-N |
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| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCNCC)c(I)c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- PC4939000
- CHEMICAL NAME :
- Methanone, (2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5 -diiodophenyl)-
- CAS REGISTRY NUMBER :
- 83409-32-9
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C23-H25-I2-N-O3
- MOLECULAR WEIGHT :
- 617.29
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1380 mg/kg/23D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in phosphorus
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,103,1991
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Synonyms
| N-Desethylamiodarone |
| Desethylamiodarone |
| N-Deethylamiodarone |
| Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl) |
| N-Monodesethylamiodarone |
| (2-butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone |
| (2-Butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone |
| Deethylamiodarone |
| Amiodarone Impurity 2 |
