Introduction：Basic information about CAS 84467-94-7|Desmethyl Sibutramine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desmethyl Sibutramine hydrochloride |
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| CAS Number | 84467-94-7 | Molecular Weight | 302.28 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C16H25Cl2N | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine,hydrochloride |
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| Synonym | More Synonyms |
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Desmethyl Sibutramine hydrochloride BiologicalActivity
| Description | Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin Transporter |
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| Target | NET and SERT[1] |
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| References | [1]. Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. [2]. Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34. [3]. Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30. [4]. Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257. |
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Chemical & Physical Properties
| Molecular Formula | C16H25Cl2N |
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| Molecular Weight | 302.28 |
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| Exact Mass | 301.13600 |
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| PSA | 12.03000 |
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| LogP | 5.58870 |
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| InChIKey | OUVFHVJVFLFXPQ-UHFFFAOYSA-N |
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| SMILES | CNC(CC(C)C)C1(c2ccc(Cl)cc2)CCC1.Cl |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| N-Desmethylsibutramine hydrochloridehydrochloride |
| Desmethyl Sibutramine,Hydrochloride Salt |
| Desmethylsibutramine hydrochloride |
| mono-Desmethylsibutramine hydrochloride |
