CAS 87679-71-8|Trandolaprilat

Introduction：Basic information about CAS 87679-71-8|Trandolaprilat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameTrandolaprilat
CAS Number87679-71-8Molecular Weight402.48400
Density1.247 g/cm3Boiling Point640.5ºC at 760 mmHg
Molecular FormulaC22H30N2O5Melting Point132-134ºC
MSDS/Flash Point341.2ºC

Names

Name(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
SynonymMore Synonyms

Trandolaprilat BiologicalActivity

DescriptionTrandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)
Target

Human Endogenous Metabolite

References

[1]. Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72.

[2]. Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.

Chemical & Physical Properties

Density1.247 g/cm3
Boiling Point640.5ºC at 760 mmHg
Melting Point132-134ºC
Molecular FormulaC22H30N2O5
Molecular Weight402.48400
Flash Point341.2ºC
Exact Mass402.21500
PSA106.94000
LogP2.62360
InChIKeyAHYHTSYNOHNUSH-HXFGRODQSA-N
SMILESCC(NC(CCc1ccccc1)C(=O)O)C(=O)N1C(C(=O)O)CC2CCCCC21
Storage condition-20°C Freezer

Safety Information

RIDADRNONH for all modes of transport
HS Code29339900

Synonyms

Trandolaprilat
Trandolaprilatum
Trandolaprilate [INN-French]
Trandolaprilatum [INN-Latin]
Trandolaprilate
UNII-RR6866VL0O
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