Introduction：Basic information about CAS 114248-23-6|2',2'-Difluoro-2'-deoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2',2'-Difluoro-2'-deoxyuridine |
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| CAS Number | 114248-23-6 | Molecular Weight | 264.183 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H10F2N2O5 | Melting Point | 147-149ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2',2'-Difluoro-2'-deoxyuridine |
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| Synonym | More Synonyms |
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2',2'-Difluoro-2'-deoxyuridine BiologicalActivity
| Description | 2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Melting Point | 147-149ºC |
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| Molecular Formula | C9H10F2N2O5 |
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| Molecular Weight | 264.183 |
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| Exact Mass | 264.055786 |
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| PSA | 104.55000 |
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| LogP | -0.53 |
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| Index of Refraction | 1.587 |
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| InChIKey | FIRDBEQIJQERSE-QPPQHZFASA-N |
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| SMILES | O=c1ccn(C2OC(CO)C(O)C2(F)F)c(=O)[nH]1 |
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| Storage condition | -20°C Freezer |
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Synonyms
| 2(1H)-Pyrimidinone, 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy- |
| 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone |
| Uridine, 2'-deoxy-2',2'-difluoro- |
| Gemcitabine impurity C |
| 2',2'-Difluoro-2'-deoxyuridine |
| 2′,2′-difluorodeoxyuridine |
| 2'-Deoxy-2',2'-difluorouridine |
