CAS 75225-50-2|Lovastatin hydroxy acid sodium

Introduction：Basic information about CAS 75225-50-2|Lovastatin hydroxy acid sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lovastatin hydroxy acid sodium BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Lovastatin hydroxy acid sodium
CAS Number	75225-50-2	Molecular Weight	444.537
Density	/	Boiling Point	602.3ºC at 760 mmHg
Molecular Formula	C₂₄H₃₇NaO₆	Melting Point	154-160ºC
MSDS	/	Flash Point	199.1ºC

Names

Name	Lovastatin sodium salt
Synonym	More Synonyms

Lovastatin hydroxy acid sodium BiologicalActivity

Description	Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Research Areas >>Metabolic Disease
Target	Ki: 0.6 nM (HMG-CoA reductase)[1]
In Vitro	Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].
References	[1]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

Chemical & Physical Properties

Boiling Point	602.3ºC at 760 mmHg
Melting Point	154-160ºC
Molecular Formula	C₂₄H₃₇NaO₆
Molecular Weight	444.537
Flash Point	199.1ºC
Exact Mass	444.248779
PSA	106.89000
LogP	2.38090
InChIKey	LXZBFUBRYYVRQJ-AXHZAXLDSA-M
SMILES	CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)[O-])C21.[Na+]

Safety Information

Hazard Codes	Xi

Synonyms

MB 530B

sodium mevinolinate

lovastatin acid sodium salt

lovastatinic sodium salt

pravastatin

lovastatin hydroxy acid sodium salt

Sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]-3,5-dihydroxyheptanoate

sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate

[1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt

1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1)

lovastatin Na

Lovastatin Hydroxy Acid

LOVASTATIN SODIUM

mevinolin sodium salt

Lovastatin Impurity 2

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