CAS 2623-22-5|15-Acetoxyscirpenol

Introduction：Basic information about CAS 2623-22-5|15-Acetoxyscirpenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 15-Acetoxyscirpenol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	15-Acetoxyscirpenol
CAS Number	2623-22-5	Molecular Weight	324.36900
Density	1.34g/cm3	Boiling Point	465.5ºC at 760mmHg
Molecular Formula	C₁₇H₂₄O₅	Melting Point	170-172 °C
MSDS	/	Flash Point	167.3ºC

Names

Name	Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate
Synonym	More Synonyms

15-Acetoxyscirpenol BiologicalActivity

Description	15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3[1].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>OthersSignaling Pathways >>Apoptosis >>Caspase
Target	Caspase
References	[1]. Lee DH, et al. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54.

Chemical & Physical Properties

Density	1.34g/cm3
Boiling Point	465.5ºC at 760mmHg
Melting Point	170-172 °C
Molecular Formula	C₁₇H₂₄O₅
Molecular Weight	324.36900
Flash Point	167.3ºC
Exact Mass	324.15700
PSA	88.52000
LogP	0.55410
Vapour Pressure	1.27E-10mmHg at 25°C
Index of Refraction	1.584
InChIKey	IRXDUBNENLKYTC-QVVXDDFFSA-N
SMILES	CC(=O)OCC12CCC(C)=CC1OC1C(O)C(O)C2(C)C12CO2
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0111000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15-acetate

CAS REGISTRY NUMBER :: 2623-22-5

LAST UPDATED :: 198709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H24-O6

MOLECULAR WEIGHT :: 324.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

Safety Information

Hazard Codes	T+
Risk Phrases	R25
RIDADR	UN 2811 6.1/PG 3
Packaging Group	II
Hazard Class	6.1(a)

Synonyms

15-MONOACETOXYSCIRPENOL

deacetylanguidin

15-MONOACETYLSCIRPENOL

15-ACETOXYSCIRPENOL

15-Acetoxyscirpen-3,4-diol

monoacetoxyscirpenol

15-Acetoxyscirpenol

Desacetylanguidine

15-acetoxyscirpendiol

15-mas

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