Introduction：Basic information about CAS 5575-21-3|Cephalonium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cephalonium |
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| CAS Number | 5575-21-3 | Molecular Weight | 458.51 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H18N4O5S2 | Melting Point | 147-150° (dec) |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | (6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
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| Synonym | More Synonyms |
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Cephalonium BiologicalActivity
| Description | Cefalonium is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| Target | β-lactam |
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| References | [1]. Harada K, et, al. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics (Basel). 2020 Apr 21;9(4):197. [2]. Demon D, et, al. The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice. Vet Microbiol. 2012 Nov 9;160(1-2):141-50. [3]. Berry EA, et, al. Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. J Dairy Sci. 2007 Feb;90(2):760-5. |
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Chemical & Physical Properties
| Melting Point | 147-150° (dec) |
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| Molecular Formula | C20H18N4O5S2 |
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| Molecular Weight | 458.51 |
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| Exact Mass | 458.07200 |
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| PSA | 190.05000 |
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| InChIKey | FMZXNVLFJHCSAF-DNVCBOLYSA-N |
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| SMILES | NC(=O)c1cc[n+](CC2=C(C(=O)[O-])N3C(=O)C(NC(=O)Cc4cccs4)C3SC2)cc1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UU2800000
- CHEMICAL NAME :
- Pyridinium, 4-carbamoyl-1-((2-carboxy-8-oxo-7-(2-(2-thienyl)aceta mido)-5-thia-1-aza- bicyclo(4.2.0)oct-2-en-3-yl)methyl)- hydroxide, inner salt
- CAS REGISTRY NUMBER :
- 5575-21-3
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H18-N4-O5-S2
- MOLECULAR WEIGHT :
- 458.54
- WISWESSER LINE NOTATION :
- T46 ANV ES GUTJ HVQ CMV1- BT5SJ& G1- AT6KJ DVZ &Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
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Safety Information
Synonyms
| Cephalonium |
| Cefalonum |
| Cefalonio [INN-Spanish] |
| Cefalonium [INN-Latin] |
| Cefalonium Hydrate |
| CEFALONIUM |
| EINECS 226-948-7 |
