Introduction：Basic information about CAS 21499-66-1|Bruceine D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bruceine D |
|---|
| CAS Number | 21499-66-1 | Molecular Weight | 410.415 |
|---|
| Density | 1.6±0.1 g/cm3 | Boiling Point | 661.3±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C20H26O9 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 235.8±25.0 °C |
|---|
Names
| Name | bruceine D |
|---|
| Synonym | More Synonyms |
|---|
Bruceine D BiologicalActivity
| Description | Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. |
|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Stem Cell/Wnt >>Notch |
|---|
| Target | Notch[1] |
|---|
| In Vitro | Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1]. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1]. |
|---|
| References | [1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205. |
|---|
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|
| Boiling Point | 661.3±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C20H26O9 |
|---|
| Molecular Weight | 410.415 |
|---|
| Flash Point | 235.8±25.0 °C |
|---|
| Exact Mass | 410.157684 |
|---|
| PSA | 153.75000 |
|---|
| LogP | -0.50 |
|---|
| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
|---|
| Index of Refraction | 1.670 |
|---|
| InChIKey | JBDMZGKDLMGOFR-RFCUIFJISA-N |
|---|
| SMILES | CC1=CC(=O)C(O)C2(C)C1CC1OC(=O)C(O)C3(O)C4(C)OCC13C2C(O)C4O |
|---|
| Storage condition | 2-8C |
|---|
Synonyms
| BRUCEIND |
| Bruceine D |
| (1β,9ξ,11β,12α,15β)-1,11,12,14,15-Pentahydroxy-13,20-epoxypicras-3-ene-2,16-dione |
| Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,9ξ,11β,12α,15β)- |
