Introduction：Basic information about CAS 6812-87-9|12-Hydroxyabieta-8,12-diene-11,14-dione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 12-Hydroxyabieta-8,12-diene-11,14-dione |
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| CAS Number | 6812-87-9 | Molecular Weight | 316.43 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 426.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H28O3 | Melting Point | / |
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| MSDS | / | Flash Point | 225.8±25.2 °C |
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Names
| Name | Royleanone |
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| Synonym | More Synonyms |
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12-Hydroxyabieta-8,12-diene-11,14-dione BiologicalActivity
| Description | Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells[1]. |
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| Related Catalog | Signaling Pathways >>PI3K/Akt/mTOR >>mTORResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>Akt |
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| Target | mTOR/PI3/AKT[1] |
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| In Vitro | Royleanone (0-200 μM; 48 h) 以剂量依赖性方式抑制 LNCaP 癌细胞的活力，IC50 为 12.5 μM[1]。 |
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| References | [1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 426.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H28O3 |
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| Molecular Weight | 316.43 |
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| Flash Point | 225.8±25.2 °C |
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| Exact Mass | 316.203857 |
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| PSA | 54.37000 |
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| LogP | 6.18 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.548 |
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| InChIKey | XBJOAZYNSZDFSF-RBZFPXEDSA-N |
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| SMILES | CC(C)C1=C(O)C2=C(C(=O)C1=O)C1(C)CCCC(C)(C)C1CC2 |
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Safety Information
Synonyms
| 1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- |
| 12-Hydroxyabieta-8,12-diene-11,14-dione |
| 1-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenan threne-3,4-dione |
| 12-Hydroxy-13-isopropylpodocarpa-8,12-diene-11,14-dione |
| 7α-12-Hydroxy-8,12-abietadiene-11,14-dione |
