Introduction：Basic information about CAS 14756-24-2|DiMNF, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DiMNF |
|---|
| CAS Number | 14756-24-2 | Molecular Weight | 332.34900 |
|---|
| Density | 1.271g/cm3 | Boiling Point | 513.8ºC at 760 mmHg |
|---|
| Molecular Formula | C21H16O4 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | 227.3ºC |
|---|
| Symbol |
GHS06 | Signal Word | Danger |
|---|
Names
| Name | 2-(3,4-dimethoxyphenyl)benzo[h]chromen-4-one |
|---|
| Synonym | More Synonyms |
|---|
DiMNF BiologicalActivity
| Description | DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1]. |
|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Aryl Hydrocarbon ReceptorResearch Areas >>Inflammation/Immunology |
|---|
| In Vitro | DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1]. DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1]. DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1]. RT-PCR[1] Cell Line: Huh7 cell Concentration: 10 μM Incubation Time: 4 h or 1 h Result: Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3. |
|---|
| References | [1]. Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79(3):508-19. |
|---|
Chemical & Physical Properties
| Density | 1.271g/cm3 |
|---|
| Boiling Point | 513.8ºC at 760 mmHg |
|---|
| Molecular Formula | C21H16O4 |
|---|
| Molecular Weight | 332.34900 |
|---|
| Flash Point | 227.3ºC |
|---|
| Exact Mass | 332.10500 |
|---|
| PSA | 48.67000 |
|---|
| LogP | 4.63040 |
|---|
| Vapour Pressure | 1.15E-10mmHg at 25°C |
|---|
| Index of Refraction | 1.65 |
|---|
| InChIKey | QDZQDIUUJDAORK-UHFFFAOYSA-N |
|---|
| SMILES | COc1ccc(-c2cc(=O)c3ccc4ccccc4c3o2)cc1OC |
|---|
Safety Information
| Symbol |
GHS06 |
|---|
| Signal Word | Danger |
|---|
| Hazard Statements | H301 |
|---|
| Precautionary Statements | P301 + P310 |
|---|
| RIDADR | UN 2811 6.1 / PGIII |
|---|
Articles1
More Articles
| Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 , e29545, (2012) The activated AHR/ARNT complex (AHRC) regulates the expression of target genes upon exposure to environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Importantly, evidence has... | |
Synonyms
| 2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one |
| 2-(3,4-dimethoxy-phenyl)-benzo[h]chromen-4-one |
| 2-(3,4-Dimethoxy-phenyl)-benzo[h]chromen-4-on |
| 2-(3,4-dimethoxyphenyl)-4h-benzo[h]chromen-4-one |
| DiMNF |
