CAS 511-89-7|Agoniadin
| Common Name | Agoniadin | ||
|---|---|---|---|
| CAS Number | 511-89-7 | Molecular Weight | 470.42 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 771.4±60.0 °C at 760 mmHg |
| Molecular Formula | C21H26O12 | Melting Point | 156-158°; mp 224-225° |
| MSDS | ChineseUSA | Flash Point | 269.2±26.4 °C |
Names
| Name | methyl (1S,4aS,7R,7aS)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[4a,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-furan]-4-carboxylate |
|---|---|
| Synonym | More Synonyms |
Agoniadin BiologicalActivity
| Description | Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
| References | [1]. Tiwari TN, et al. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother Res. 2002 Jun;16(4):393-4. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 771.4±60.0 °C at 760 mmHg |
| Melting Point | 156-158°; mp 224-225° |
| Molecular Formula | C21H26O12 |
| Molecular Weight | 470.42 |
| Flash Point | 269.2±26.4 °C |
| Exact Mass | 470.142426 |
| PSA | 181.44000 |
| LogP | -4.23 |
| Vapour Pressure | 0.0±6.0 mmHg at 25°C |
| Index of Refraction | 1.645 |
| InChIKey | AOPMSFXOYJXDNJ-IRFSQMTFSA-N |
| SMILES | COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1C=CC21C=C(C(C)O)C(=O)O1 |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles5
More Articles| Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon. J. Ethnopharmacol. 147(2) , 474-80, (2013) Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.To investigate the in vivo genotoxic... | |
| Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest. J. Nat. Prod. 60(12) , 1294-7, (1997) Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isopl... | |
| Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity. J. Org. Chem. 69(19) , 6165-72, (2004) Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituent... |
Synonyms
| 1-(b-D-Glucopyranosyloxy)-4a,7a-dihydro-4'-(1-hydroxyethyl)-5'-oxospiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic Acid Methyl Ester |
| Spiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-4a,7a-dihydro-4'-[(1S)-1-hydroxyethyl]-5'-oxo-, methyl ester, (1S,4aS,7R,7aS)- |
| Agoniadin |
| Methyl (1S,4aS,7R,7aS)-1-(β-D-glucopyranosyloxy)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-4a,7a-dihydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate |
| Plumieride |
