CAS 75277-39-3|HEPES sodium salt
| Common Name | HEPES sodium salt | ||
|---|---|---|---|
| CAS Number | 75277-39-3 | Molecular Weight | 260.286 |
| Density | / | Boiling Point | / |
| Molecular Formula | C8H17N2NaO4S | Melting Point | 234ºC |
| MSDS | USA | Flash Point | / |
Names
| Name | sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate |
|---|---|
| Synonym | More Synonyms |
HEPES sodium salt BiologicalActivity
| Description | HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | HEPES maintains superhydrophilicity of titanium for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity[1]. HEPES drives lysosome biogenesis, affects MiT/TFE cytoplasmic-nuclear distribution, disrupts global cellular transcriptional profiles, resulting the activation of a MiT/TFE-dependent lysosomal-autophagic gene network in cultured RAW264.7 cells[3]. |
| References | [1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. https://pubmed.ncbi.nlm.nih.gov/20631430/ |
Chemical & Physical Properties
| Melting Point | 234ºC |
|---|---|
| Molecular Formula | C8H17N2NaO4S |
| Molecular Weight | 260.286 |
| Exact Mass | 260.080658 |
| PSA | 92.29000 |
| InChIKey | RDZTWEVXRGYCFV-UHFFFAOYSA-M |
| SMILES | O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+] |
| Storage condition | Store at RT. |
| Stability | Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents. |
| Water Solubility | H2O: 1 M at 20 °C, clear, colorless |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29335995 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles37
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Synonyms
| 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) |
| HEPES sodium salt |
| EINECS 278-169-7 |
| Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate |
| MFCD00036463 |
| 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt |
