CAS 9002-13-5|Urea

Introduction:Basic information about CAS 9002-13-5|Urea, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameUrea
CAS Number9002-13-5Molecular Weight60.055
Density1.6±0.1 g/cm3Boiling Point165.1±23.0 °C at 760 mmHg
Molecular FormulaC2H6Melting Point/
MSDSChineseUSAFlash Point53.7±22.6 °C
Symbol
GHS07, GHS08
Signal WordDanger

Names

NameEthane
SynonymMore Synonyms

Urea BiologicalActivity

DescriptionUrease is produced by many types of bacteria and is an effective virulence factor for some pathogenic bacteria. Urease is also central to the metabolism and virulence of Helicobacter pylori, helping it colonize the stomach lining[1].
Related CatalogResearch Areas >>OthersSignaling Pathways >>Anti-infection >>Bacterial
References

[1]. Mobley H L T, et al. Urease[J]. Helicobacter pylori: physiology and genetics, 2001: 177-191.

Chemical & Physical Properties

Density1.6±0.1 g/cm3
Boiling Point165.1±23.0 °C at 760 mmHg
Molecular FormulaC2H6
Molecular Weight60.055
Flash Point53.7±22.6 °C
Exact Mass60.032364
LogP-1.43
Vapour Pressure0.6±0.7 mmHg at 25°C
Index of Refraction1.528
Storage condition2-8°C
Water SolubilityIt is slightly soluble in water.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU1700000
CHEMICAL NAME :
Urease
CAS REGISTRY NUMBER :
9002-13-5
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3123 No. of Facilities: 1133 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 14585 (estimated) No. of Female Employees: 9975 (estimated)

Safety Information

Symbol
GHS07, GHS08
Signal WordDanger
Hazard StatementsH315-H319-H334-H335
Precautionary StatementsP261-P305 + P351 + P338-P342 + P311
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard CodesXn
Risk PhrasesR36/37/38
Safety PhrasesS22-S24-S26-S36/37-S45-S36-S23
RIDADRNONH for all modes of transport
WGK Germany1
RTECSYU1700000

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Synonyms

Carbonyl diamide
Urea
Carbamide
carbonyl diamine
MFCD00070858
Urea (8CI,9CI)
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