Introduction：Basic information about CAS 870223-96-4|AMG-Tie2-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AMG-Tie2-1 |
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| CAS Number | 870223-96-4 | Molecular Weight | 479.454 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C25H20F3N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzamide |
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| Synonym | More Synonyms |
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AMG-Tie2-1 BiologicalActivity
| Description | AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C25H20F3N5O2 |
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| Molecular Weight | 479.454 |
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| Exact Mass | 479.156921 |
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| PSA | 95.75000 |
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| LogP | 4.78 |
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| Index of Refraction | 1.630 |
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| InChIKey | ZVIWALRWYYSHSU-UHFFFAOYSA-N |
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| SMILES | CNc1nccc(-c2cccnc2Oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)n1 |
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Synonyms
| 4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide |
| AMG-Tie2 |
| 4-Methyl-3-({3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide |
| 4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide |
| pyridylpyrimidine ether 4 |
| AMG-Tie2-1 |
| Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- |
