CAS 9004-62-0|Hydroxyethyl cellulose
Introduction：Basic information about CAS 9004-62-0|Hydroxyethyl cellulose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxyethyl cellulose | ||
|---|---|---|---|
| CAS Number | 9004-62-0 | Molecular Weight | 154.25100 |
| Density | 0.75 g/mL at 25ºC(lit.) | Boiling Point | / |
| Molecular Formula | C4H10O2S2 | Melting Point | 288-290ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Hydroxyethyl Cellulose |
|---|---|
| Synonym | More Synonyms |
Hydroxyethyl cellulose BiologicalActivity
| Description | Hydroxyethyl cellulose is a non-ionic, water soluble, modified cellulose polymer used as a thickening agent for aqueous cosmetic and personal care formulations. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| In Vitro | Stabilization of graphene oxide in physiological solution is performed using hydroxyethyl cellulose to make the resultant nanohybrid suitable for targeted drug delivery purposes. Hydroxyethyl cellulose effectively stabilizes graphene oxid in electrolyte solutions and the mechanism of stabilization appears to be depended on hydroxyethyl cellulose content. Hydroxyethyl cellulose content in the nanohybrid plays an important role in final application to make it applicable either as a carrier for controllable drug release or as a folate-targeted drug carrier[1]. Hydroxyethyl cellulose shows superior cryoprotective effects on LDH during freeze thawing, and considerable lyoprotective effects during the freeze drying process. Annealing has limited influence on the stabilizing effect of hydroxyethyl cellulose. The extensive reconstitution times of the hydroxyethyl cellulose lyophilisates could be greatly improved by incorporation of the surfactant Tween 80 into the formulations prior to freeze drying[2]. |
| References | [1]. Mianehrow H, et al. Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82. [2]. Al-Hussein A, et al. Investigation of the stabilizing effects of hydroxyethyl cellulose on LDH during freeze drying and freeze thawing cycles. Pharm Dev Technol. 2015 Jan;20(1):50-9. |
Chemical & Physical Properties
| Density | 0.75 g/mL at 25ºC(lit.) |
|---|---|
| Melting Point | 288-290ºC (dec.) |
| Molecular Formula | C4H10O2S2 |
| Molecular Weight | 154.25100 |
| Exact Mass | 154.01200 |
| PSA | 91.06000 |
| LogP | 0.35240 |
| InChIKey | CWSZBVAUYPTXTG-UHFFFAOYSA-N |
| SMILES | COC1C(CO)OC(OCC2OC(OC3C(CO)OC(C)C(O)C3O)C(O)C(O)C2OC2OC(CO)C(OC)C(O)C2OCCO)C(O)C1O |
| Storage condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides |
| Water Solubility | H2O: ≤5 wt. % at 20 °C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 5100 mg/kg/6D-I
- TOXIC EFFECTS :
- Brain and Coverings - increased intracranial pressure Behavioral - somnolence (general depressed activity) Vascular - change in plasma or blood volume
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 317,964,1987 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 3-7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year: 149,282,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82127 No. of Facilities: 8381 (estimated) No. of Industries: 70 No. of Occupations: 62 No. of Employees: 95547 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82127 No. of Facilities: 27127 (estimated) No. of Industries: 167 No. of Occupations: 124 No. of Employees: 749900 (estimated) No. of Female Employees: 369916 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | T |
| Risk Phrases | R23/24/25 |
| Safety Phrases | 26-36-45-24/25-22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | FJ5958000 |
| HS Code | 3912390000 |
Customs
| HS Code | 3912390000 |
|---|
Articles35
More Articles| Effects of different amine fluoride concentrations on enamel remineralization. J. Dent. 40(9) , 750-5, (2012) The aim of this study was to investigate the effects of decreasing fluoride concentrations on repeated demineralizing challenges on human enamel.In 24 teeth, 3mm×3mm windows were prepared on the bucca... | |
| Disposable polyester-toner electrophoresis microchips for DNA analysis. Analyst 137(11) , 2692-8, (2012) Microchip electrophoresis has become a powerful tool for DNA separation, offering all of the advantages typically associated with miniaturized techniques: high speed, high resolution, ease of automati... | |
| Effect of fluoride, lesion baseline severity and mineral distribution on lesion progression. Caries Res. 46(1) , 23-30, (2012) The present study investigated the effects of fluoride (F) concentration, lesion baseline severity (ΔZ(base)) and mineral distribution on lesion progression. Artificial caries lesions were created usi... |
Synonyms
| MFCD00072770 |
| 2,2'-Disulfanediyldiethanol |
| EINECS 618-387-5 |
