Introduction：Basic information about CAS 1235126-46-1|Linderaspirone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Linderaspirone A |
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| CAS Number | 1235126-46-1 | Molecular Weight | 600.61 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 826.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C34H32O10 | Melting Point | / |
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| MSDS | / | Flash Point | 340.9±34.3 °C |
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Names
| Name | (6E,8R,14E,16R)-2,3,6,11,12,14-Hexamethoxy-8,16-diphenyldispiro[4 .3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone |
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| Synonym | More Synonyms |
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Linderaspirone A BiologicalActivity
| Description | Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 [1][2]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>PGE synthase |
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| In Vitro | Linderaspirone A also inhibits the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, and the activation of nuclear factor κB (NF-κB) [2]. |
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| References | [1]. Lin Chen, et al. Lindera cyclopentenedione intermediates from the roots of Lindera aggregate. RSC Adv. 2018 May 16;8(32):17898-17904. [2]. Chi-Su Yoon, et al. Effects of Compounds Isolated from Lindera erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage. Int J Mol Sci. 2022 Jun 27;23(13):7122. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 826.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C34H32O10 |
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| Molecular Weight | 600.61 |
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| Flash Point | 340.9±34.3 °C |
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| Exact Mass | 600.199524 |
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| PSA | 123.66000 |
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| LogP | 3.40 |
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| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
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| Index of Refraction | 1.615 |
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| InChIKey | OASRMBZSJNAYKB-FGZHOGPDSA-N |
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| SMILES | COC1=CC(c2ccccc2)C2(C(=O)C(OC)=C(OC)C2=O)C(OC)=CC(c2ccccc2)C12C(=O)C(OC)=C(OC)C2=O |
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Safety Information
Synonyms
| Dispiro[4.3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone, 2,3,6,11,12,14-hexamethoxy-8,16-diphenyl-, (6E,8R,14E,16R)- |
| (6E,8R,14E,16R)-2,3,6,11,12,14-Hexamethoxy-8,16-diphenyldispiro[4.3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone |
