Introduction：Basic information about CAS 1225497-78-8|ON-01910, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ON-01910 |
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| CAS Number | 1225497-78-8 | Molecular Weight | 473.47 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H24NNaO8S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Rigosertib |
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| Synonym | More Synonyms |
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ON-01910 BiologicalActivity
| Description | Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>OthersSignaling Pathways >>Cell Cycle/DNA Damage >>Polo-like Kinase (PLK) |
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| Target | PLK1 |
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| In Vitro | Rigosertib (ON-01910) sodium 是一种非 ATP 竞争性 PLK1 抑制剂，IC50 为 9 nM，比 Plk2 选择性高 30 倍，对 Plk3 没有抑制活性。 |
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| References | [1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86. |
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Chemical & Physical Properties
| Molecular Formula | C21H24NNaO8S |
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| Molecular Weight | 473.47 |
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| Exact Mass | 473.112030 |
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| PSA | 131.60000 |
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| LogP | 2.62230 |
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| Storage condition | -20℃ |
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Synonyms
| Glycine, N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt (1:1) |
| Sodium {[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl]amino}acetate |
| ON-01910 |
| Estybon |
| Sodium {[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfo nyl}methyl)phenyl]amino}acetate |
