Introduction：Basic information about CAS 219773-55-4|AS602868, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AS602868 |
|---|
| CAS Number | 219773-55-4 | Molecular Weight | 366.39 |
|---|
| Density | 1.475 | Boiling Point | / |
|---|
| Molecular Formula | C18H14N4O3S | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | 1-[(5-methoxy-2-thiophen-2-ylquinazolin-4-yl)amino]-3-methylpyrrole-2,5-dione |
|---|
| Synonym | More Synonyms |
|---|
AS602868 BiologicalActivity
| Description | SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1]. |
|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
|---|
| In Vivo | SPC 839 (compound 10) (30 mg/kg, p.o., 21 days) 在佐剂诱导的关节炎大鼠模型中显示显著活性，使未注射足部肿胀减少 65%[1]。 |
|---|
| References | [1]. Moorthy S S Palanki, et al. The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4077-80. |
|---|
Chemical & Physical Properties
| Density | 1.475 |
|---|
| Molecular Formula | C18H14N4O3S |
|---|
| Molecular Weight | 366.39 |
|---|
| Exact Mass | 366.07900 |
|---|
| PSA | 115.89000 |
|---|
| LogP | 2.36870 |
|---|
| InChIKey | GZGLPBNOIFLLRE-UHFFFAOYSA-N |
|---|
| SMILES | COc1cccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c12 |
|---|
Synonyms
