Introduction：Basic information about CAS 870070-55-6|Tozadenant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tozadenant |
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| CAS Number | 870070-55-6 | Molecular Weight | 406.499 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C19H26N4O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-methylpiperidine-1-carboxamide |
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| Synonym | More Synonyms |
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Tozadenant BiologicalActivity
| Description | Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adenosine ReceptorResearch Areas >>Neurological Disease |
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| Target | Ki: 6 nM (Rhesus A2A), 11.5 nM (Human A2A) |
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| In Vivo | 18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant[1]. |
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| References | [1]. Olivier Barret, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nucl Med. 2014 Oct;55(10):1712-8. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C19H26N4O4S |
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| Molecular Weight | 406.499 |
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| Exact Mass | 406.167480 |
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| PSA | 118.89000 |
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| LogP | 0.43 |
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| Index of Refraction | 1.662 |
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| InChIKey | XNBRWUQWSKXMPW-UHFFFAOYSA-N |
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| SMILES | COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-hydroxy-n-(4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl)-4-methyl-1-piperidinecarboxamide |
| 4-hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide |
| Tozadenant |
| SYN-115 |
| 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide |
| 4-Hydroxy-N-(4-methoxy-7-morpholinobenzo(d)thiazol-2-yl)-4-methylpiperidine-1-carboxamide |
| Tozadenant (USAN) |
| 1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl- |
| 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide |
