Introduction：Basic information about CAS 867257-26-9|Tecarfarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tecarfarin |
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| CAS Number | 867257-26-9 | Molecular Weight | 460.32300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H14F6O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yl) 4-[(4-hydroxy-2-oxochromen-3-yl)methyl]benzoate |
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| Synonym | More Synonyms |
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Tecarfarin BiologicalActivity
| Description | Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2]. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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| Target | VKOR[1] |
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| References | [1]. Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117(11):2009-2011. [2]. Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126(5):e383-8. |
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Chemical & Physical Properties
| Molecular Formula | C21H14F6O5 |
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| Molecular Weight | 460.32300 |
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| Exact Mass | 460.07500 |
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| PSA | 76.74000 |
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| LogP | 5.12950 |
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| InChIKey | QFLNTQDOVCLQKW-UHFFFAOYSA-N |
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| SMILES | CC(OC(=O)c1ccc(Cc2c(O)c3ccccc3oc2=O)cc1)(C(F)(F)F)C(F)(F)F |
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Synonyms
| tecarfarin |
| ati-5923 |
| unii-wn1479yt50 |
