Introduction：Basic information about CAS 594839-88-0|Tafamidis, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tafamidis |
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| CAS Number | 594839-88-0 | Molecular Weight | 308.116 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 486.7±40.0 °C at 760 mmHg |
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| Molecular Formula | C14H7Cl2NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 248.1±27.3 °C |
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Names
| Name | tafamidis |
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| Synonym | More Synonyms |
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Tafamidis BiologicalActivity
| Description | Tafamidis(Fx1006A) is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.Target: OthersTafamidis is a drug for the amelioration of transthyretin-related hereditary amyloidosis.Tafamidis functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein. Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants, are also stabilized by tafamidis binding. The crystal structure of tafamidis-bound TTR suggests that binding stabilizes the weaker dimer-dimer interface against dissociation, the rate-limiting step of amyloidogenesis [1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| References | [1]. Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 486.7±40.0 °C at 760 mmHg |
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| Molecular Formula | C14H7Cl2NO3 |
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| Molecular Weight | 308.116 |
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| Flash Point | 248.1±27.3 °C |
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| Exact Mass | 306.980286 |
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| PSA | 63.33000 |
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| LogP | 5.29 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.677 |
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| InChIKey | TXEIIPDJKFWEEC-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)- |
| Tafamidis |
| 8FG9H9D31J |
| 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid |
| UNII-8FG9H9D31J |
| FX-1006 |
| 3MI |
