Introduction：Basic information about CAS 203120-17-6|Laninamivir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Laninamivir |
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| CAS Number | 203120-17-6 | Molecular Weight | 346.34 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C13H22N4O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-2,3-dihydroxy-1-methoxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid |
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| Synonym | More Synonyms |
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Laninamivir BiologicalActivity
| Description | Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
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| Target | IC50: 0.90 nM (N5), 1.83 nM (p09N1), 3.12 nM (p57N2)[1] |
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| In Vitro | Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1]. Laninamivir is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1]. |
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| References | [1]. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C13H22N4O7 |
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| Molecular Weight | 346.34 |
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| Exact Mass | 346.148834 |
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| PSA | 190.71000 |
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| LogP | -3.06 |
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| Index of Refraction | 1.634 |
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| InChIKey | QNRRHYPPQFELSF-CNYIRLTGSA-N |
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| SMILES | COC(C(O)CO)C1OC(C(=O)O)=CC(N=C(N)N)C1NC(C)=O |
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Synonyms
| 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-7-O-methyl-D-glycero-D-galacto-non-2-enopyranosoic acid |
| Laninamivir |
| CS-8958 |
| (6R)-5-Acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-6-[(1R,2R)-2,3-dihydroxy-1-methoxypropyl]-L-threo-hex-2-enonic acid |
| D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl- |
