CAS 202914-84-9|Lomitapide Mesylate

Introduction：Basic information about CAS 202914-84-9|Lomitapide Mesylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lomitapide Mesylate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Lomitapide Mesylate
CAS Number	202914-84-9	Molecular Weight	789.82600
Density	/	Boiling Point	/
Molecular Formula	C₄₀H₄₁F₆N₃O₅S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	lomitapide mesylate
Synonym	More Synonyms

Lomitapide Mesylate BiologicalActivity

Description	Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.IC50 value: 8 nM [1]Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease
References	[1]. Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70. [2]. Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11(5):347-52. [3]. Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J Cardiovasc Drugs. 2013 Aug;13(4):285-96.

Description

Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.IC50 value: 8 nM [1]Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease

References

[1]. Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.

[2]. Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11(5):347-52.

[3]. Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J Cardiovasc Drugs. 2013 Aug;13(4):285-96.

Chemical & Physical Properties

Molecular Formula	C₄₀H₄₁F₆N₃O₅S
Molecular Weight	789.82600
Exact Mass	789.26700
PSA	131.17000
LogP	10.31990
InChIKey	QKVKOFVWUHNEBX-UHFFFAOYSA-N
SMILES	CS(=O)(=O)O.O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1
Storage condition	-20℃

Synonyms

methanesulfonic acid,N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

UNII-X4S83CP54E

AEGR-733

Lomitapide mesylate

Juxtapid

Lomitapide (mesylate)

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