CAS 677746-25-7|K 01-162

Introduction：Basic information about CAS 677746-25-7|K 01-162, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. K 01-162 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	K 01-162
CAS Number	677746-25-7	Molecular Weight	288.18200
Density	/	Boiling Point	/
Molecular Formula	C₁₅H₁₄BrN	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	7-Bromo-N,N-dimethyl-9H-fluoren-2-amine
Synonym	More Synonyms

K 01-162 BiologicalActivity

Description	K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo：K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2]
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Amyloid-βResearch Areas >>Neurological Disease
References	[1]. Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100(4):1076-82. [2]. Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31(10):1690-9.

Description

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo：K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2]

Related Catalog

Signaling Pathways >>Neuronal Signaling >>Amyloid-βResearch Areas >>Neurological Disease

References

[1]. Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100(4):1076-82.

[2]. Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31(10):1690-9.

Chemical & Physical Properties

Molecular Formula	C₁₅H₁₄BrN
Molecular Weight	288.18200
Exact Mass	287.03100
PSA	3.24000
LogP	4.08630
InChIKey	KABXKWWJTYSDTD-UHFFFAOYSA-N
SMILES	CN(C)c1ccc2c(c1)Cc1cc(Br)ccc1-2
Storage condition	2-8℃

Synonyms

K 01-162

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