Introduction：Basic information about CAS 21730-16-5|Metapramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Metapramine |
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| CAS Number | 21730-16-5 | Molecular Weight | 238.32800 |
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| Density | 1.12g/cm3 | Boiling Point | 350.8ºC at 760mmHg |
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| Molecular Formula | C16H18N2 | Melting Point | / |
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| MSDS | / | Flash Point | 140.7ºC |
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Names
| Name | N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine |
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| Synonym | More Synonyms |
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Metapramine BiologicalActivity
| Description | Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1] [2] [3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| Target | NMDA receptor complex channel[4] |
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| In Vivo | Metapramine (19560 RP) (0-20 mg/kg; i.p.) shows analgesic effects in mice[5]. Animal Model: Male Swiss albino mice[5] Dosage: 0-20 mg/kg Administration: Intraperitoneal injection Result: Increased jump latency, threshold voltage, reduction in writhes, and tail flick latency in a dose-dependent manner. |
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| References | [1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23. [2]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. [3]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70. [4]. A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7. [5]. Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9. |
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Chemical & Physical Properties
| Density | 1.12g/cm3 |
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| Boiling Point | 350.8ºC at 760mmHg |
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| Molecular Formula | C16H18N2 |
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| Molecular Weight | 238.32800 |
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| Flash Point | 140.7ºC |
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| Exact Mass | 238.14700 |
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| PSA | 15.27000 |
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| LogP | 3.72700 |
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| Vapour Pressure | 4.27E-05mmHg at 25°C |
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| Index of Refraction | 1.633 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
