Introduction：Basic information about CAS 38230-32-9|dehydrocurdione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | dehydrocurdione |
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| CAS Number | 38230-32-9 | Molecular Weight | 234.33400 |
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| Density | 0.962g/cm3 | Boiling Point | 362.9ºC at 760 mmHg |
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| Molecular Formula | C15H22O2 | Melting Point | / |
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| MSDS | / | Flash Point | 136.2ºC |
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Names
| Name | (6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione |
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| Synonym | More Synonyms |
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dehydrocurdione BiologicalActivity
| Description | Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2]. |
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| Related Catalog | Signaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Inflammation/Immunology |
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| In Vitro | Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM[1]. Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer[1]. Western Blot Analysis[1] Cell Line: RAW 264.7 cells Concentration: 100 μM Incubation Time: 24 hours Result: Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr. |
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| In Vivo | Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis[2]. Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema[2]. Animal Model: Wistar rats[2] Dosage: 120 mg/kg Administration: P.o ; daily for 12 days Result: Significantly reduces chronic adjuvant arthritis. |
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| References | [1]. Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897. [2]. Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481. |
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Chemical & Physical Properties
| Density | 0.962g/cm3 |
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| Boiling Point | 362.9ºC at 760 mmHg |
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| Molecular Formula | C15H22O2 |
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| Molecular Weight | 234.33400 |
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| Flash Point | 136.2ºC |
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| Exact Mass | 234.16200 |
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| PSA | 34.14000 |
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| LogP | 3.61740 |
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| Index of Refraction | 1.477 |
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| InChIKey | ZYPUZCWWTYIGFV-DSDFTUOUSA-N |
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| SMILES | CC1=CCCC(C)C(=O)CC(=C(C)C)C(=O)C1 |
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Synonyms
