CAS 85144-11-2|Lithium chloride monohydrate
| Common Name | Lithium chloride monohydrate | ||
|---|---|---|---|
| CAS Number | 85144-11-2 | Molecular Weight | 60.40930 |
| Density | 1.21 g/mL at 20 °C | Boiling Point | 1382 °C |
| Molecular Formula | ClH2LiO | Melting Point | 605 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | -4 °F |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | lithium chloride hydrate |
|---|---|
| Synonym | More Synonyms |
Lithium chloride monohydrate BiologicalActivity
| Description | Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>GSK-3Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>InfectionResearch Areas >>Neurological DiseaseSignaling Pathways >>PI3K/Akt/mTOR >>GSK-3 |
| Target | GSK-3β |
| In Vitro | Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV Beaudette 感染的 BHK 细胞中的细胞病变和 IBV 复制[1]。 Lithium chloride hydrate (5 和 20 mM，36 小时) 抑制 IBV 诱导的 BHK 细胞凋亡和炎症[1]。 Lithium chloride hydrate (1 mg/mL) 提高诱导多能干细胞衍生神经球的效率[4]。 Lithium chloride hydrate (1.2 mM，72 小时) 保护 PC12 细胞免受 Morphine (HY-P1701) 诱导的细胞凋亡[5]。 RT-PCR[1] Cell Line: BHK cells Concentration: 5 and 20 mM Incubation Time: 36 h Result: Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β. Blocked levels of Caspase-3, Bax and increased Bcl-2 level. |
| In Vivo | Lithium chloride hydrate (60 mg/kg，i.p.，每天两次) 改善 Sevoflurane (SEV) 诱导的大鼠记忆障碍[2]。 Lithium chloride hydrate (150 mg/kg，口服，每隔一天) 刺激大鼠拔牙窝修复中的骨形成[6]。 Animal Model: Rats[5] Dosage: 150 mg/kg Administration: Oral administration (p.o.), every other day Result: Produced greater proportion of newly formed bone (NB). Lowered the rate of TRAP-stained cells. Animal Model: Sevoflurane-induced memory impairment rats[2] Dosage: 60 mg/kg Administration: Intraperitoneal injection (i.p.), twice a day. Result: Reduced escape latency, increased time in the objective quadrant and raised platform crossings. Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus. |
| References | [1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [2]. Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [3]. Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45(5):605-613. [4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [5]. Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48. |
Chemical & Physical Properties
| Density | 1.21 g/mL at 20 °C |
|---|---|
| Boiling Point | 1382 °C |
| Melting Point | 605 °C(lit.) |
| Molecular Formula | ClH2LiO |
| Molecular Weight | 60.40930 |
| Flash Point | -4 °F |
| Exact Mass | 59.99540 |
| PSA | 9.23000 |
| Appearance of Characters | beads |
| Index of Refraction | n20/D 1.381 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | F,Xn |
| Risk Phrases | 11-36/37/38-22 |
| Safety Phrases | S16-S26 |
| RIDADR | UN 2789 8/PG 2 |
| WGK Germany | 1 |
| RTECS | OJ5950000 |
Articles1
More Articles| A high-performance moisture sensor based on ultralarge graphene oxide. Nanoscale 7 , 17805-11, (2015) This article describes the effect of the lateral size of graphene oxide (GO) on the humidity sensing properties of a GO-based sensor. The GO size effect on the humidity sensing performance was evaluat... |
Synonyms
| lithium chloride hydrate,puratronic |
| EINECS 231-212-3 |
| Lithium hcloride monohydrate |
| Lithium chloride hydrate,Puratronic,99.9 (metals basis) |
| LITHIUM CHLORIDE MONOHYDRATE |
| Lithium chloride hydrate,99. metals basis |
| hydrate/monohydrateortrihydrate |
| LITHIUM CHLORIDE 1-HYDRATE |
| Lithium chloride hydrate,Puratronic(R),99.9 (metals basis) |
| Lithium chloride,Ionization Buffer Solution,Specpure|r |
| MFCD00149764 |
