Introduction：Basic information about CAS 38691-95-1|Groenlandicine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Groenlandicine |
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| CAS Number | 38691-95-1 | Molecular Weight | 321.32700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C19H16NO4+ | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Dehydrocheilanthifoline |
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| Synonym | More Synonyms |
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Groenlandicine BiologicalActivity
| Description | Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase |
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| Target | Topoisomerase I |
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| References | [1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12. [2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8. |
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Chemical & Physical Properties
| Molecular Formula | C19H16NO4+ |
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| Molecular Weight | 321.32700 |
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| Exact Mass | 321.10000 |
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| PSA | 48.64000 |
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| LogP | 1.44980 |
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| InChIKey | PGIOBGCIEGZHJH-UHFFFAOYSA-O |
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| SMILES | COc1cc2c(cc1O)CC[n+]1cc3c4c(ccc3cc1-2)OCO4 |
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| Storage condition | 2-8℃ |
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Synonyms
| Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium,11,12-dihydro-9-hydroxy-8-methoxy |
| Tetradehydrocheilanthiofolinium |
| Groenlandicine |
| Tetradehydrocheilanthifoline |
