Introduction：Basic information about CAS 110429-45-3|m-PEG4-Br, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | m-PEG4-Br |
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| CAS Number | 110429-45-3 | Molecular Weight | 271.14900 |
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| Density | 1.256g/cm3 | Boiling Point | 296.3ºC at 760 mmHg |
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| Molecular Formula | C9H19BrO4 | Melting Point | / |
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| MSDS | / | Flash Point | 118.8ºC |
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Names
| Name | Triethylene Glycol 2-Bromoethyl Methyl Ether |
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| Synonym | More Synonyms |
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m-PEG4-Br BiologicalActivity
| Description | m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
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| Target | Cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
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| References | [1]. Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988. |
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Chemical & Physical Properties
| Density | 1.256g/cm3 |
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| Boiling Point | 296.3ºC at 760 mmHg |
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| Molecular Formula | C9H19BrO4 |
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| Molecular Weight | 271.14900 |
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| Flash Point | 118.8ºC |
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| Exact Mass | 270.04700 |
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| PSA | 36.92000 |
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| LogP | 1.07750 |
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| Vapour Pressure | 0.00256mmHg at 25°C |
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| Index of Refraction | 1.454 |
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| InChIKey | YFFFQGXWMHAJPP-UHFFFAOYSA-N |
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| SMILES | COCCOCCOCCOCCBr |
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| Storage condition | 2-8°C |
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Synonyms
| 1-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-2-methoxyethane |
| Triethylene Glycol 2-BroMoethyl Methyl Ether |
| 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide |
| 1-Bromo-3,6,9,12-tetraoxatridecane |
