CAS 149385-65-9|Amyloid β-Protein (31-35)

Introduction：Basic information about CAS 149385-65-9|Amyloid β-Protein (31-35), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amyloid β-Protein (31-35) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Amyloid β-Protein (31-35)
CAS Number	149385-65-9	Molecular Weight	545.73600
Density	1.137 g/cm3	Boiling Point	866.382ºC at 760 mmHg
Molecular Formula	C₂₅H₄₇N₅O₆S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	h-ile-ile-gly-leu-met-oh
Synonym	More Synonyms

Amyloid β-Protein (31-35) BiologicalActivity

Description	β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Amyloid-βPeptidesResearch Areas >>Neurological Disease
In Vitro	β-Amyloid (31-35) is a functional cytotoxic domain of Aβ peptide. β-Amyloid (31-35) increases the phosphorylation of biotinylated Aβ(1-40), enhances CDK-1 activity, and also inhibits binding of Aβ to cyclin B1. β-Amyloid (31-35) is cytotoxic, and such an effect can be inhibited by olomoucine in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons[1]. β-Amyloid (31-35) shows cytotoxic effect on cerebellar granule cells (CGC). β-Amyloid (31-35) also increases caspase-3 activity in a time-dependent manner (4-24 h) at 40 μM[2].
References	[1]. Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322(2):131-3. [2]. Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49(5):525-32.

Chemical & Physical Properties

Density	1.137 g/cm3
Boiling Point	866.382ºC at 760 mmHg
Molecular Formula	C₂₅H₄₇N₅O₆S
Molecular Weight	545.73600
Exact Mass	545.32500
PSA	205.02000
LogP	3.12420
InChIKey	ZMDGLWRNBGRYQB-ZKHIMWLXSA-N
SMILES	CCC(C)C(N)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)O)C(C)CC
Storage condition	−20°C

Synonyms

IIGLM

Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine

amyloid B-protein fragment 31-35*acetate

ILE-ILE-GLY-LEU-MET

Amyloid β-Protein (31-35)

β-Amyloid (31-35)

Recommended......