Introduction：Basic information about CAS 2150-43-8|Protocatechuic acid methyl ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Protocatechuic acid methyl ester |
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| CAS Number | 2150-43-8 | Molecular Weight | 168.147 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 351.5±22.0 °C at 760 mmHg |
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| Molecular Formula | C8H8O4 | Melting Point | 134-135°C |
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| MSDS | / | Flash Point | 148.5±15.8 °C |
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Names
| Name | Methyl 3,4-dihydroxybenzoate |
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| Synonym | More Synonyms |
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Protocatechuic acid methyl ester BiologicalActivity
| Description | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1]. |
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| Related Catalog | Signaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>CancerNatural Products >>Acids and AldehydesResearch Areas >>Inflammation/Immunology |
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| In Vitro | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) alleviates the toxic effects of F- via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells[1]. |
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| In Vivo | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) (25 or 50 mg/kg bw/day) prevents the cellular F- accumulation and oxidative stress. It prevents the inflammatory and associated fibrosis progression by restoring the expression of RAGE and Nrf2[2]. |
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| References | [1]. Ameeramja J, et al. Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):941-950. [2]. Ameeramja J, et al. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018 Aug;118:235-244. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 351.5±22.0 °C at 760 mmHg |
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| Melting Point | 134-135°C |
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| Molecular Formula | C8H8O4 |
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| Molecular Weight | 168.147 |
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| Flash Point | 148.5±15.8 °C |
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| Exact Mass | 168.042252 |
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| PSA | 66.76000 |
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| LogP | 1.69 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.588 |
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| InChIKey | CUFLZUDASVUNOE-UHFFFAOYSA-N |
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| SMILES | COC(=O)c1ccc(O)c(O)c1 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| HS Code | 2918290000 |
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Customs
| HS Code | 2918290000 |
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| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 3,4-DIHYDROXY-BENZOIC ACID METHYL ESTER |
| 3,4-dihydroxy methyl benzoate |
| MFCD00016437 |
| 3,4-Dihydroxybenzoic Acid Methyl Ester |
| Protocatechuic acid,methyl ester |
| 3,4-dihydroxy-6-methoxycarbonylbenzene |
| Methyl 3,4-dihydroxybenzoate |
| Protocatechuic Acid Methyl Ester |
| Benzoic acid, 3,4-dihydroxy-, methyl ester |
| Methyl Protocatechuate |
