Introduction：Basic information about CAS 877130-28-4|Filibuvir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Filibuvir |
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| CAS Number | 877130-28-4 | Molecular Weight | 503.63600 |
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| Density | 1.29g/cm3 | Boiling Point | / |
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| Molecular Formula | C29H37N5O3 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | (2R)-2-cyclopentyl-2-[2-(2,6-diethylpyridin-4-yl)ethyl]-5-[(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-3H-pyran-6-one |
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| Synonym | More Synonyms |
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Filibuvir BiologicalActivity
| Description | Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HCV Protease |
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| References | [1]. Wagner F, et al. Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients. Hepatology. 2011 Jul;54(1):50-9. |
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Chemical & Physical Properties
| Density | 1.29g/cm3 |
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| Molecular Formula | C29H37N5O3 |
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| Molecular Weight | 503.63600 |
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| Exact Mass | 503.29000 |
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| PSA | 102.50000 |
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| LogP | 5.12420 |
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| Appearance of Characters | white to beige |
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| InChIKey | SLVAPEZTBDBAPI-GDLZYMKVSA-N |
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| SMILES | CCc1cc(CCC2(C3CCCC3)CC(O)=C(Cc3nc4nc(C)cc(C)n4n3)C(=O)O2)cc(CC)n1 |
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| Storage condition | room temp |
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| Water Solubility | DMSO: soluble10mg/mL, clear |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Filibuvir |
| 3frz |
| UNII-198J479Y2L |
