CAS 127-65-1|Chloramine-T

CHEMICAL IDENTIFICATION

RTECS NUMBER :

XT5616800

CHEMICAL NAME :

p-Toluenesulfonamide, N-chloro-, sodium salt

CAS REGISTRY NUMBER :

127-65-1

LAST UPDATED :

199710

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C7-H8-Cl-N-O2-S.Na

MOLECULAR WEIGHT :

228.66

WISWESSER LINE NOTATION :

GMSWR DI &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Parenteral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Parenteral

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Human Lymphocyte

DOSE/DURATION :

100 ppm/24H

REFERENCE :

ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950- Volume(issue)/page/year: 21,409,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83916 No. of Facilities: 93 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 378 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83916 No. of Facilities: 190 (estimated) No. of Industries: 7 No. of Occupations: 8 No. of Employees: 1829 (estimated) No. of Female Employees: 1284 (estimated)