CAS 546-88-3|Acetohydroxamic acid
Introduction：Basic information about CAS 546-88-3|Acetohydroxamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acetohydroxamic acid | ||
|---|---|---|---|
| CAS Number | 546-88-3 | Molecular Weight | 75.067 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 231.4ºC at 760 mmHg |
| Molecular Formula | C2H5NO2 | Melting Point | 88-90 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | acetohydroxamic acid |
|---|---|
| Synonym | More Synonyms |
Acetohydroxamic acid BiologicalActivity
| Description | Acetohydroxamic acid is a potent and irreversible inhibitor of bacterial and plant urease and also used as adjunctive therapy in chronic urinary infection.Target: UreaseAcetohydroxamic acid selectively inhibits arachidonate 5-lipoxygenase and thus has potential use in the treatment of asthma. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
| References | [1]. Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52(1):76-82. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 231.4ºC at 760 mmHg |
| Melting Point | 88-90 °C(lit.) |
| Molecular Formula | C2H5NO2 |
| Molecular Weight | 75.067 |
| Exact Mass | 75.032028 |
| PSA | 49.33000 |
| LogP | -1.59 |
| Index of Refraction | 1.421 |
| InChIKey | RRUDCFGSUDOHDG-UHFFFAOYSA-N |
| SMILES | CC(=O)NO |
| Stability | Moisture and Temperature Sensitive |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 750 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 20 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 20 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R61 |
| Safety Phrases | S53-S45 |
| RIDADR | 3263 |
| WGK Germany | 3 |
| RTECS | AK8157000 |
| Packaging Group | II |
| HS Code | 2942000000 |
Customs
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles108
More Articles| CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc. Natl. Acad. Sci. U. S. A. 112 , 5875-82, (2015) Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis reve... | |
| BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1. J. Neurosci. 35(3) , 972-84, (2015) Although the MAP kinase-interacting kinases (MNKs) have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here, we explore the involvement of the MNKs... | |
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
Synonyms
| Acetamide, N-hydroxy- |
| Acetohydroxamic acid |
| methanecarbohydroxamic acid |
| EINECS 208-913-8 |
| N-Hydroxyacetamide |
| N-acetylhydroxylamine |
| Acetomenadione |
| acethydroxamic acid |
| methylenehydroxamic acid |
| Acetylhydroxylamine |
| AHA |
| Lithostat |
| Acethydroxamsaure |
| MFCD00009994 |
| Acetohydroxamic |
| Acetic acid,oxime |
| Acetic Acid Oxime |
