CAS 54-96-6|3,4-Diaminopyridine
Introduction：Basic information about CAS 54-96-6|3,4-Diaminopyridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-Diaminopyridine | ||
|---|---|---|---|
| CAS Number | 54-96-6 | Molecular Weight | 109.129 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 369.3±22.0 °C at 760 mmHg |
| Molecular Formula | C5H7N3 | Melting Point | 216-218 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 204.9±9.5 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 3,4-Diaminopyridine |
|---|---|
| Synonym | More Synonyms |
3,4-Diaminopyridine BiologicalActivity
| Description | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases.Target: OthersAmifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate. A 2005 systematic review from the Cochrane Collaboration found some data favouring its use in LEMS. Amifampridine is also used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. From Wikipedia. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| References | [1]. http://en.wikipedia.org/wiki/3,4-Diaminopyridine#cite_note-4 |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 369.3±22.0 °C at 760 mmHg |
| Melting Point | 216-218 °C(lit.) |
| Molecular Formula | C5H7N3 |
| Molecular Weight | 109.129 |
| Flash Point | 204.9±9.5 °C |
| Exact Mass | 109.063995 |
| PSA | 64.93000 |
| LogP | -0.09 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.676 |
| InChIKey | OYTKINVCDFNREN-UHFFFAOYSA-N |
| SMILES | Nc1ccncc1N |
| Water Solubility | 24 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,296,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 150,413,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H330-H311-H315-H319-H335 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25;R36/37/38 |
| Safety Phrases | S26-S28-S36/37/39-S45-S37/39-S28A |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | US7600000 |
| Packaging Group | I |
| Hazard Class | 6.1 |
| HS Code | 29333999 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3-Pyridinamine, 1,4-dihydro-4-imino- |
| 3,4-Pyridinedramine |
| 3,4-DIAMINOPYRIDINE FOR SYNTHESIS |
| 3,4-Diaminopyridin |
| 3,4-DAP |
| 3,4-diamino-pyridine |
| 3,4-diamino-pyridin |
| 3,4-Diaminopyridine |
| Amifampridine |
| 3 4-DIAMINOPYRIDINE |
| Pyridine-3,4-diamine |
| pyridin-3,4-diaMine |
| 4,5-diaminopyridine |
| 3,4DIAMINOPYRIDINE |
| EINECS 200-220-9 |
| 3,4 DI AMINO PYRIDINE |
| Pyridin-3,4-diamin |
| 3-amino-4-pyridinylamine |
| MFCD00006401 |
| 3,4-Pyridinediamine |
| diamino-3,4pyridine |
